By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. Yes it aids absorption, you get it all at once, and that's not good. If a pill is enteric coated and not scored it is not meant to be crushed. Tablets should be swallowed whole, never crushed or chewed. Seroquel XR: Tablets are available in 50mg, 150mg, 200mg, 300mg, and 400mg dosages. The time-release formulation is designed to maintain a steady level of medication in your body throughout the day. The List of Oral Dosage Forms That Should Not Be Crushed, commonly referred to as the Do Not Crush list, contains medications that should not be crushed because of their special pharmaceutical formulations or characteristics, such as oral dosage forms that are sustained-release in nature. These effects occur because once Seroquel is crushed into a powder, it becomes a particle material. The nasal passages and respiratory tract are not meant to handle these materials. The nasal passages and respiratory tract are not meant to handle these materials. Not advisable because it is time released and when crushed that messes it and the medicine is released unevenly. The majority of extended-release products should not be crushed or chewed, although there are some newer slow-release tablet formulations available that are scored and can be divided or halved (e.g., Toprol XL). Seroquel is the brand name of the generic drug quetiapine, used to treat schizophrenia and bipolar disorder (formerly known as manic-depression). The BIG question is how many milligrams the Seroquel tablet is. The second question is why he is crushing it in the first place. If it is Seroquel XR it should NEVER be crushed. The Seroquel should work crushed and mixed into food. The issue I see is does he eat some food right before he goes to bed? Having the pill with dinner is not likely to work. The issue I see is does he eat some food right before he goes to bed?.